– Carmona earthquake. (1504)
– The expansion of the Chapel of the Virgen de la Antigua begins. (1504)
– The Cathedral was inaugurated on May 11. (1507) The tomb of Cardinal Diego Hurtado de Mendoza is placed in the Chapel of the Virgen de la Antigua. (1510)
– The primitive dome that covers the transept of the Cathedral collapses. (1511)
– The railings of the choir and the southern side of the Main Chapel are finished. (1523)
– The Main Altarpiece is finished. (1526)
– Diego de Riaño begins the Sacristía Mayor. (1528)
– The Sacristy of the Chalices is finished. (1534)
– The mausoleum of D. Baltasar del Río, bishop of Scalas, is placed in the Chapel of Scalas. (1539)
– The construction of the current Royal Chapel begins. (1547)
– The Main Sacristy is finished. (1547)
– The enlargement of the Main Altarpiece begins. (1549)
– Hernán Ruiz begins the construction of the Chapterhouse and the current bell tower of the Giralda. (1558)
– Completion of the altar of La Gamba next to the Puertade San Cristóbal. (1561)
– The enlargement of the Main Altarpiece is completed. (1564)
– Work on the monumental weathervane, the Giraldillo, is encouraged for its completion. (1565)
– The choir lectern is finished (1565).
– Completion of the Giraldillo and the growth of the bell tower. (1568)
– Completion of the façade of the Chapel of the Virgen de la Antigua. (1571)
– The Royal Chapel and the Main Chapel are finished. (1575)
– Transfer of the pillar with the fresco of the Virgin of Antigua to the Chapel of her name. (1578)
– Reforms in the Puerta del Perdón. (1578)
– Transfer of the remains of Ferdinand III, his wife and Alfonso X to the new Royal Chapel. (1579)
– Juan de Arfe presents the model of his Custody to the Cabildo. (1580)
– Completion of the Antecabildo, designed in 1560 by Hernán Ruiz. (1583)
– The painting of San Cristóbal next to the Gate of his name is finished. (1584)
– Completion of the Chapter House. (1592)